Author

Hua-Long Zheng

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Aug 2026

Midkine-activated TRPA1+ cancer-associated fibroblasts promote immunotherapy resistance in gastric cancer through a WNT5A-mediated treg circuit

This study unveils an MDK-TRPA1 + CAF-mediated mechanism of ICB resistance in GC and highlights the WNT5A-SPP1+ macrophage pathway as a promising target to overcome immunotherapy resistance.

Hua-Long Zheng, Xiao-Qian Ye, Lin-Yong Zheng et al. · Oncogene · 0 citations