Open access
Oct 2026
Disruption of p62 ubiquitination by α-methylene-γ-butyrolactone enhances Keap1 lysosomal degradation for ulcerative colitis therapy.
Ulcerative colitis (UC) is an intestinal inflammatory disorder primarily driven by M1 macrophage activation and oxidative stress. p62/Sequestosome-1, a multifunctional autophagy adaptor protein, plays a critical role in regulating autophagy and inflammation. α-Methylene-γ-butyrolactone (αMγB), a conserved structural mo...
Ke-Gang Linghu, Da-Song Wang, Tian Zhang et al.
· Redox Biology · 0 citations