Open access
Oct 2026
Heterogeneity in secondary follicle development buffers the lifespan of activated oocytes to optimize female fertility in mice.
Oocyte activation and follicular development are fundamental for fertility in mammals, yet the dynamics of activated oocytes (Act-Oos) remain unclear. Here we use a Zp3-based lineage-tracing mouse model to label Act-Oos and reconstruct their developmental trajectories and folliculogenesis across the lifespan. We uncove...
Jing Liang, Xue-Bing Yang, Qian Li et al.
· Nature Aging · 0 citations