Aug 2026
ZCCHC4-mediated m6A methylation regulates the UHRF1/CDO1 axis to inhibit ferroptosis and promote osteosarcoma malignant progression.
This study reveals for the first time the complete molecular mechanism by which ZCCHC4-mediated UHRF1 m6A methylation promotes OS progression through epigenetic suppression of CDO1 transcription and inhibition of ferroptosis.
Kai Song, Ju Liu, Bo-Wen Han et al.
· Bone · 0 citations