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Author

Hua Zhou

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Aug 2026

Splenic extramedullary hematopoiesis in myelofibrosis is shaped by transcriptomic and epigenetic dysregulation.

Myelofibrosis (MF) is a chronic, progressive myeloproliferative neoplasm characterized by bone marrow fibrosis, ineffective blood cell production, and neoplastic extramedullary hematopoiesis (EMH) occurring primarily within the spleen. To explore the molecular mechanisms underlying splenic EMH, we performed single-cell...

Rebecca Austin, Madeline H. Kowalski, Xiaoli Wang et al. · 2 citations
Open access Jul 2026

Pan-cancer proteogenomic interrogation of the ubiquitin-proteasome system.

An integrated pan-cancer analysis of UPS protein dysregulation, prognostic associations, and mutation-driven remodeling shows that mRNA poorly predicts UPS protein abundance, that a defined set of E3 ligases is recurrently dysregulated across cancers, and that somatic mutations produce coherent UPS protein-quantitative...

Tania J. González-Robles, M. Khan, Paul Sastourné et al. · 0 citations

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