Hepatocellular carcinoma (HCC) is characterized by high heterogeneity, a complex tumor microenvironment, and multiple physiological barriers that limit conventional therapies and cause significant toxicity. Drug delivery systems (DDS), particularly nanoscale delivery systems, offer promising opportunities to overcome t...
Gui-Wen Liang, Chu-Lin Zhu, Hua-Lin Sun et al.· Drug Design, Development and...· 0 citations
Abstract The mechanosensitive ion channel Piezo1 translates physical cues from the tumor microenvironment—including extracellular matrix stiffness, fluid shear stress, and compressive forces—into intracellular calcium signals and downstream cascades, playing a pivotal role in cancer. Piezo1 exhibits pronounced tumor-ty...
Hai-Yan Jiang, Ying Liu, Fei Xue et al.· Drug Design, Development and...· 0 citations
Abstract Breast cancer heterogeneity and its complex tumor microenvironment (TME) are key drivers of therapeutic failure and multidrug resistance (MDR). Drug delivery systems (DDS) provide an important approach, but their clinical translation remains limited by biological variability, formulation complexity, and manufa...
Gui-Wen Liang, Chu-Lin Zhu, Hua-Lin Sun et al.· Drug Design, Development and...· 0 citations
Overall, DAMP-directed intervention in skeletal muscle will likely require selective and context-dependent modulation that limits pathological inflammation while preserving physiological repair and regeneration.
Zi-Hui Gao, Xia Li, Ya-Nan Ji et al.· Biochemical Pharmacology· 0 citations
Current mechanistic insights inspire targeted therapeutic strategies comprising α-synuclein inhibitors, mitochondrial protectants, anti-inflammatory agents, and novel cell death pathway blockers, alongside gut-brain axis interventions for PD, but these approaches face substantial challenges.
Abstract Amyotrophic lateral sclerosis (ALS) is a highly heterogeneous and fatal neurodegenerative disorder, for which clinical management and drug development have long faced formidable challenges. Since the approval of riluzole and edaravone, dozens of promising drug candidates that showed efficacy in preclinical mod...
Yutong Wei, Jie Wang, Ya-Nan Ji et al.· Drug Design, Development and...· 0 citations
How neuroendocrine alterations drive downstream molecular mechanisms-specifically neuroinflammation, a shift in the kynurenine pathway, mitochondrial dysfunction, and impaired brain-derived neurotrophic factor (BDNF) signaling-that collectively remodel stress-related brain circuits are explored.
Xia Li, Yanbei Zhu, Ya-Nan Ji et al.· Biochemical Pharmacology· 2 citations
Receptor-interacting protein kinase 3 (RIPK3) is classically recognized as a central executor of necroptosis, but accumulating evidence indicates that its functions extend beyond lytic cell death. RIPK3 regulates metabolic processes, inflammatory signaling, organelle homeostasis, and stress responses through both kinas...
Yun-Tian Shen, Haiyan Jiang, Jie Wang et al.· Biochemical Pharmacology· 0 citations
The molecular mechanisms underlying major cell death pathways are summarized and their context-dependent roles in skeletal muscle physiology are discussed, including development, adaptation, regeneration, and aging, as well as in disease progression.
Jiahuan Gong, Hong-Yi Xu, Yun-Tian Shen et al.· European Journal of Pharmaco...· 4 citations
The cGAS-STING pathway has emerged as a central hub linking kidney injury to inflammation, metabolism, and fibrosis, and its precise modulation holds transformative therapeutic promise for hundreds of millions of patients with kidney diseases worldwide.
Guang-Dong Qi, Fei Xue, Hua-Lin Sun et al.· Frontiers in Pharmacology· 3 citations
A novel perspective on the inflammatory mechanisms underlying diabetes mellitus and its complications is provided, thereby establishing a theoretical foundation for the development of therapeutic strategies centered on modulating the cGAS-STING pathway.
Guang-Dong Qi, Tong-Xin Shang, Hua-Lin Sun et al.· Frontiers in Pharmacology· 0 citations
BACKGROUND AND PURPOSE
The molecular mechanisms underlying denervation-induced muscle atrophy remain incompletely understood, and effective therapeutic interventions are currently lacking. Tectorigenin (TG), a natural isoflavonoid, has demonstrated antioxidant and metabolic regulatory activities. This study investigate...
Boya Liu, Fei Xue, Xingxing Fang et al.· British Journal of Pharmacol...· 2 citations
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