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Huan-Huan Yang

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Open access Aug 2026

Unconventional role of hydroxymethylglutaryl-CoA synthase 1 in driving pathogenic TH17 cell immunity and autoimmune diseases

This work unveils a noncanonical axis in which HMGCS1 sustains ER stress to license pTH17 differentiation during autoimmune responses, and thereby unveils a noncanonical axis in which pTH17 immunity and mitigates autoimmune disease in vivo are revealed.

Jie Sun, Ya-Li Lei, Huan-Huan Yang et al. · Science Advances · 0 citations