Huan-Le Wang

Potassium channels as an ionic checkpoint in tumor immunity

Potassium (K+) channels sustain immune-cell activation by coupling K+ flux to membrane potential, Ca2+ signaling, migration, and metabolic adaptation. In solid tumors, however, extracellular K+ accumulation, adenosine, hypoxia, acidosis, oxidative stress, and lipid stress can disrupt ionic homeostasis and channel funct...