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Open access Sep 2026

S100A8/A9-TMEM24 axis drives podocyte injury by impairing autophagy: a novel theranostic target for early diabetic nephropathy.

OBJECTIVE To establish a comprehensive theranostic framework for early-stage diabetic kidney disease (DKD) by validating serum S100A8/A9 as a highly sensitive diagnostic biomarker and exploring therapeutic strategies targeting the S100A9/transmembrane protein 24 (TMEM24) signaling axis to restore podocyte autophagy....

Jia-Sen Shi, Heng Wang, Liu Xu et al. · 0 citations

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