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Oct 2026

Tumor microenvironment-responsive size-switchable nanoplatforms integrating focused ultrasound achieve highly efficient synergistic chemo-starvation antitumor therapy.

Insufficient intratumoral accumulation and penetration remain major barriers that limit the therapeutic efficacy of nanotechnology-based drug delivery systems (NDDSs). Herein, tumor microenvironment-responsive size-switchable carrier-free nanoplatforms (GMFD NPs) are constructed using glucose oxidase (GOD), Fe3+, MnO2...

Qi Wang, He-Chun Li, Yu Zhang et al. · 0 citations
Open access Aug 2026

Hydroxyapatite-mineralized metal-organic frameworks as sonosensitizer modulate tumor microenvironment to potentiate high-intensity focused ultrasound therapy

Bone-derived hydroxyapatite-mineralized metal-organic frameworks as sonosensitizer as sonosensitizer co-encapsulated Zn2+, hypoxic-activated prodrug AQ4N, and STING agonist SR-717 for acoustic-immunological synergistic therapy for acoustic-immunological synergistic therapy improves ablation efficiency and treats residu...

Xiaomei Xie, Qi Wang, Hanlin Song et al. · 0 citations

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