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An inherent T cell-activating polymer-lipid nanoparticle that enables ligand-free, efficient mRNA transfection and activation of T cells in vivo, and provides a clinically translatable approach for in vivo CAR T cell generation.
This review systematically dissects how functional polymer engineering-including interfacial shielding, targeted ligand modification, membrane perturbation, and stimuli-responsive disassembly-facilitates systemic circulation, antigen-presenting cell uptake, endosomal escape, and intracellular cargo release.
This review examines non-viral and non-lipid RNA nanocarriers from mechanistic and translational perspectives and highlights non-viral and non-lipid nanocarriers as complementary platforms for context-specific RNA therapy.
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