Hui-Chan Yuan

Integration of multi-omics Mendelian randomization, neuroimaging mediation, and functional validation identifies PYGL as a neuroprotective causal gene for stroke prognosis.

A causal gene regulatory network underlying stroke prognosis is delineated, the importance of neuronal energy metabolism and oligodendrocyte function in recovery is highlighted, and PYGL is nominated as a potential therapeutic target for promoting functional recovery after ischemic stroke.