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Author

Hui-Chun Zhan

2 papers indexed here

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Review Sep 2026

Telomeres in Aging: Links to Clonal Hematopoiesis, Cardiovascular Disease, and Cancer.

Telomeres protect chromosome ends and help preserve genomic integrity. Progressive telomere shortening with each cell division functions as a biologic clock that contributes to limited human lifespan. When telomeres become critically short with aging, DNA damage responses are activated, leading to cellular senescence o...

Hao-Yi Zheng, Hui-Chun Zhan · 0 citations
Review Aug 2026

Novel murine models of hematopoietic-endothelial crosstalk in JAK2V617F-associated cardiovascular disease.

Cardiovascular disease (CVD) is a major complication of JAK2V617F-positive myeloproliferative neoplasms (MPNs), yet the mechanisms linking mutant hematopoiesis to CVD remain incompletely understood. We developed three complementary murine models to delineate the role of hematopoietic-endothelial crosstalk in JAK2V617F-...

Hao-Yi Zheng, Hui-Chun Zhan · 0 citations

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