DNA Nanoassembly Modified Polydopamine@MnO2 Nanoparticles: Enhancement of miRNA-21 Downregulation for Reversal of Breast Cancer Drug-Resistance.
Downregulating oncogenic microRNAs (miRNAs) is an attractive strategy for reversing drug resistance in cancer therapy. Compared to antisense, DNAzyme (Dz) possesses advantages such as recyclability and stability. However, it still suffers from insufficient stability and inadequate endogenous cofactors. Herein, by using...