Open access
Oct 2026
Fusion-loop-engineered Zika mRNA vaccine elicits convergent B cell immunodominance to uncouple protection from ADE in macaques.
Antibody-dependent enhancement (ADE) remains a major hurdle for flavivirus vaccine development. Engineering the fusion loop (FL) represents a promising solution, yet validations restricted to murine models limit human translatability due to profound species divergence. Here, we provide a primate-level demonstration tha...
Chen-Xi Yang, Shu-Xin Guo, Ya-Ming Lu et al.
· Cell Reports Medicine · 0 citations