Open access
Oct 2026
Single-nucleus transcriptomics uncovers region-specific molecular features underlying selective aging vulnerability of cholinergic neurons
Summary Cholinergic neurons exhibit functional and molecular heterogeneity across the basal forebrain (BF), midbrain (MB), and brainstem (BS), while the aging-associated transcriptional features remain poorly characterized. Here, we performed single nucleus RNA sequencing (snRNA-seq) on 108,062 nuclei from the MS/VDB,...
Qian-Qian Li, Jia-Le Chen, Xiu-Li Liu et al.
· iScience · 0 citations