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Oct 2026

Design, Synthesis and Evaluation Donepezil-Based Dual BuChE/FAAH Inhibitors for Alzheimer’s Disease Therapy

Alzheimer’s disease (AD) is multifactorial, prompting multi-target therapy. A series of donepezil-based derivatives were designed, synthesized, and evaluated as dual inhibitors of human butyrylcholinesterase (hBuChE) and fatty acid amide hydrolase (hFAAH). Among them, lead G15 displayed potent and balanced inhibition...

Xiao-Dan Liu, Yin-Xin Wu, Yu-Lu Ding et al. · 0 citations
Open access Sep 2026

Carboxymethylated Poria cocos Polysaccharides Mitigate Cisplatin‐Induced Hepatorenal Injury by Activating the PLC‐PKC‐Nrf2 Signaling Pathway

ABSTRACT Cisplatin, a commonly used chemotherapy drug, inevitably causes damage to the liver and kidneys while exerting its anti‐tumor effects. Carboxymethylated Poria cocos polysaccharides (CMP) have anti‐inflammatory, antioxidant, and organ‐protective properties, and also exhibit significant anti‐tumor activity. Ther...

Liang He, Shuo Chen, Bao-Min Wu et al. · 0 citations

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