Open access
Aug 2026
The continuous accumulation of genetic mutations in influenza A viruses (IAVs) drives antigenic drift, necessitating precise antigenic prediction for optimal vaccine strain selection. While sequence-based methods have advanced antigenic surveillance, they neglect the three-dimensional structural context that fundamenta...
Xing-Yi Li, Chun-Yan Zhou, Ke-Xin Xiao et al.
· bioRxiv · 0 citations
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Open access
Sep 2026
MOTIVATION
Human influenza A/H3N2 viruses undergo rapid antigenic evolution primarily driven by the hemagglutinin subunit 1 (HA1). Within HA1, amino acid substitutions under immune pressure cause antigenic drift, necessitating frequent updates to vaccine strains. While hemagglutination inhibition (HI) assays remain the...
Xing-Yi Li, Ke-Xin Xiao, Chun-Yan Zhou et al.
· Bioinformatics · 0 citations
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Open access
Jul 2026
The identification of VHH5, a nanobody targeting conserved residues within the neuraminidase active site of the influenza B virus, conferring broad inhibitory activity is reported, establishing VHH5-Fc as a promising therapeutic candidate with potent and broad-spectrum activity against antigenically diverse IBV strains...
Hang Jia, Chaohui Lin, Yinghao Guo et al.
· Journal of Virology · 0 citations
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