Hepatic Macrophage STING Signaling in Liver Fibrosis: Mechanisms and Therapeutic Perspectives.
Liver fibrosis (LF) arises from chronic liver injury, in which a persistently pro-inflammatory microenvironment shaped by hepatic macrophages drives hepatic stellate cells (HSCs) activation and fibrosis progression. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway serves as a molecular...