Sep 2026
Baicalein from Scutellaria baicalensis Allosterically Inhibits TMPRSS2 and Suppresses Coronavirus Entry
Transmembrane protease serine 2 (TMPRSS2) is an important host serine protease involved in the activation of viral envelope glycoproteins. To identify natural bioactive constituents that modulate TMPRSS2, we screened extracts from 28 natural product extracts using an affinity-guided ligand fishing approach. Four flav...
Jie Mei, Fan Zhang, Jie Deng et al.
· Journal of Natural Products · 0 citations