Hui-Meng Lei

Reward contingency reorganizes lateral orbitofrontal cortex pyramidal neuron activity from reward-aligned to action-aligned during associative learning

Background Animals must learn not only which cues predict reward, but also when to act to obtain it. Although the orbitofrontal cortex (OFC) encodes reward-related information, whether reward contingency is sufficient to reorganize the temporal alignment of OFC activity remains unclear. Methods We recorded calcium sign...