OBJECTIVES
Paediatric-onset immune-mediated inflammatory diseases (IMIDs), including juvenile idiopathic arthritis and related rheumatic diseases, remain genetically undercharacterised. We aimed to define shared and category-specific genetic architecture across paediatric IMIDs, compare signals with adult IMIDs, and id...
Jin Li, Hui-Qi Qu, Michael E. March et al.· Annals of the Rheumatic Dise...· 0 citations
CNS-related conditions span tumors, vascular, neurodevelopmental, and psychiatric disorders, yet therapeutic development for CNS disorders continues to face persistent delays and high attrition due to blood–brain barrier constraints, biological heterogeneity, and limited predictive models. Drug repurposing can shorten...
Yi-Chuan Liu, Hui-Qi Qu, F. Mentch et al.· Neurotherapeutics· 0 citations
Prostate cancer (PCa) is a prevalent male cancer with high survival rates, except in advanced or metastatic stages, for which effective treatments are lacking. Metastatic PCa involves complex mechanisms including loss of tumor suppressor genes and DNA repair molecules, which impacts therapy responses. Analyses of t...
M. Rodrigo-Faus, I. Del Monte-Garcia, Marina Hermosilla-Trespaderne et al.· Scientific Reports· 0 citations
Deep generative models have transformed biological sequence modeling from predictive analysis toward increasingly controllable design. Early biological applications of Variational Autoencoders (VAEs) and Generative Adversarial Networks (GANs) established latent representation learning and sequence synthesis, while rece...
