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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Hui Shi

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Open access Sep 2026

BAFF-APRIL blockade reveals isotype-specific pathogenic autoantibody remodelling in antiphospholipid syndrome.

OBJECTIVES Durable suppression of pathogenic autoantibodies remains a central challenge in antibody-mediated autoimmune diseases. We aimed to examine pathogenic autoantibody remodelling under targeted humoral immunotherapy using antiphospholipid syndrome (APS) as a tractable human model. METHODS In this study, we use...

Hao-Yu Pan, Xiao-Han Wei, Shi-Yang Gu et al. · 0 citations
Open access Sep 2026

mRNA-encoding CD19-targeting T cell engager for refractory immune thrombocytopenia.

In a first-in-human study involving three patients with refractory secondary immune thrombocytopenia, ABO2203 achieved rapid and complete peripheral B cell depletion, with sustained depletion in bone marrow, establishing mRNA-encoded TCEs as a potent and safer therapeutic modality for B cell-mediated autoimmune disease...

Meng-Yan Wang, Ting-Ting Liu, Qi Dai et al. · 0 citations

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