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Review Open access Sep 2026

Isolated MSH2 Loss With Divergent Microsatellite Instability Status in Colorectal and Prostate Adenocarcinoma: A Diagnostic Pitfall.

BackgroundThe fidelity of the DNA mismatch repair (MMR) system is routinely evaluated using MMR immunohistochemistry (IHC). The MMR IHC is interpreted based on obligate heterodimeric relationships (MLH1-PMS2; MSH2-MSH6). MSH2 loss typically results in concurrent MSH6 loss. Atypical non-dimer patterns, such as isolated...

Pramath Kakodkar, Hui Wang · 0 citations

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