Author

Hui-Wen Luan

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Review Open access Sep 2026

Tumour-associated dsRNA accumulation and innate immune activation: mechanistic basis and therapeutic strategies

This Review examines critical-target and cumulative-burden models, methods for ligand identification, biomarker-guided patient selection and therapeutic strategies based on viral mimicry, ADAR1 targeting, engineered dsRNA agonists, and delivery platforms.

Shao-Ping Li, Yan-Fei Huo, Hang-Wei Fa et al. · EBioMedicine · 0 citations

Jul 2026

CLOCK confers EGFR-TKIs resistance in non-small cell lung cancer by transcriptionally upregulating LAMC2 expression and activating multiple kinase signaling.

Findings for the first time identify CLOCK as a critical mediator of EGFR-TKIs resistance and a promising target to overcome EGFR-TKIs resistance in NSCLC.

Yan-Kang Li, Lin-Yu Han, Hui-Wen Luan et al. · Archives of Biochemistry and... · 0 citations