Author

Hui-Yong Zhao

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Open access Aug 2026

ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer

Together, these data show that ZFP36L2 acts as an important molecular switch that couples stress sensing with phenotypic plasticity, which in turn drives cellular dedifferentiation essential for re-establishing the ISC state during wound healing and metastasis.

Qi Jiang, Manisha S. Raghavan, Aileen M. Rodriguez et al. · Nature · 0 citations

Open access Jul 2026

IL-1β/IL-6 signaling circuit in the tumor microenvironment drives prostate cancer development

A pro-tumorigenic IL-1β/IL-6 signaling circuit mediated through local macrophages and fibroblasts is identified that unleashes the full oncogenic potential of a cancer driver activated at the PIN stage, with implications for TME-specific targeted therapeutics in early-stage disease.

Young-Sun Lee, Jimmy L. Zhao, Agnieszka Chryplewicz et al. · bioRxiv · 0 citations