Author

Huiqin Xu

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Open access Aug 2026

DYNAMIC CONFORMATIONS IN THE ACTIVATION OF PINK1 KINASE

It is reported that Tribolium castaneum PINK1 (TcPINK1) forms specific symmetric dimers via interactions between the kinase N-lobe and the regulatory C-terminal domain, which provide a framework for understanding the conformational plasticity and allosteric regulation of PINK1 in mitophagy.

Huiqin Xu, Xin-Yang Liu, Yan Jiang et al. · bioRxiv · 0 citations

Open access Aug 2026

MOLECULAR BASIS FOR PINK1 MATURATION

A general mechanism for PINK1 recognition by the HSP90α/CDC37/FKBP51 chaperone complex is revealed and a potential approach for upregulating PINK1 activity, which is impaired in PD is suggested.

Junrong Xue, Huiqin Xu, Yanfeng Zhang et al. · bioRxiv · 0 citations