Immune-checkpoint blockade has changed cancer therapy, yet durable responses remain limited by immune exclusion, myeloid suppression and metabolic adaptation within the tumor immune microenvironment. Ferroptosis, an iron-dependent form of lipid-peroxidation-driven regulated cell death, offers a mechanistic bridge bet...
This review critically synthesizes the multifaceted roles of RNA modifications to bridge the gap between descriptive epitranscriptomic mapping and functional tumor biology, and aims to facilitate the translation of epitranscriptomic findings into clinical applications.
This review systematically consolidates recent advances in understanding how lncRNAs precisely modulate Notch pathway activity through diverse mechanisms, including acting as competing endogenous RNAs, direct protein binding, epigenetic regulation, and exosome-mediated intercellular communication.
Qing-Miao Shi, Na Lou, Huiwu Xing et al.· Frontiers in Cell and Develo...· 0 citations
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