Open access
Sep 2026
Papillary Thyroid Carcinoma with Terminal Immune Exhaustion Phenotype Correlates with Increased Risk of Lymph Node Metastasis: An Exploratory Study Combining Flow Cytometry and TCGA
It was found that LNM-positive PTC exhibited a terminal immune exhaustion phenotype characterized by enrichment of PD-1hiTIM-3+ CD8+ T cells and regulatory T cells and regulatory T cells, alongside elevated pro-inflammatory cytokines.
Shiwei Wang, Huizhu Cai, Ruo-Chan Zhang et al.
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