Author

Humaira Nadeem

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Open access Sep 2026

Computational, In Vitro, and In Vivo Evaluation of Benzimidazole–Pyrazole Hybrid Scaffolds as Multi‐Target Anti‐Ulcer Agents

Peptic ulcer disease (PUD) continues to be an important gastrointestinal condition attributed to Helicobacter pylori infection, usage of nonsteroidal anti‐inflammatory drugs, oxidative stress, and inflammatory mediators. Although there are available treatments for this condition, side effects, relapse, and safety issue...

Hafiz Aamir Ali Kharl, Abdul Malik, Humaira Nadeem et al. · Chemistry and Biodiversity · 0 citations

Open access Sep 2026

Benzamides of 2-(aminophenyl)benzimidazoles and 2-(aminophenyl)indoles as Anticancer Scaffolds: Synthesis, In Silico and In Vitro Evaluation

This study provides a pathway for the synthesis of 2-phenylbenzimidazoles and 2-phenylindoles and demonstrates that the synthetic compound 4-APB-B possesses remarkable selective cytotoxic activity and can serve as a lead molecule for further development into a successful anticancer agent.

A. Saeed, Humaira Nadeem, F. Malik et al. · Pharmaceuticals · 0 citations

Aug 2026

Design, Synthesis, In Silico and In Vitro Analysis of Newly Synthesized 2-Mercaptobenzazole Derivatives as Potential Acetylcholinesterase Inhibitors.

The consistency between molecular docking, enzyme inhibition, and kinetic findings suggests that substituent-driven interactions play an important role in AChE inhibition, and their potential as lead scaffolds for the development of novel multitarget therapeutic candidates for Alzheimer's disease is supported.

Iqra Zulfqar, Syed Muzzammil Masaud, Asma Bukhari et al. · Current Medicinal Chemistry · 0 citations