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Hung-Yu Chen

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Review Open access Aug 2026

Resistance to PD-1/PD-L1 blockade: Mechanism and pharmacological strategies

This review synthesizes the current landscape of PD-1/PD-L1-directed ICIs, dissect the molecular and cellular determinants of intrinsic and acquired resistance, and discusses emerging pharmacological strategies to overcome them, including next-generation checkpoint combinations.

A. Kim, Nawon Lee, Hung-Yu Chen et al. · 0 citations

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