Huiqing Zeng

Direct detection of alternative DNA conformations with long-read sequencing and machine learning approaches

Progress has been made in identifying G-quadruplexes (G4s) and other non-canonical (non-B) DNA structures in live cells. However, these experiments have been limited by methodological constraints, including low resolution and specificity, and GC-sequencing bias inherent to the short-read sequencing technologies. Direct...