Combinations of terminal selector transcription factors (tsTFs) are thought to establish and maintain the unique identities of the numerous cell types found in nervous systems. However, it remains largely unclear how tsTF combinations are specified during development, and how they then coordinate the type-specific diff...
McKenzie Treese, Yen-Chung Chen, Abigail Tyree et al.· Proceedings of the National...· 1 citation
Cth1 is a highly deposited maternal mRNA that undergoes rapid decay 3’UTR of Cth1 drives its spatio-temporal dynamics, establishing Cth1 as a key component of the maternal program and providing the first direct evidence that spatio-temporally regulated mRNA decay, outside the germline, contributes to early vertebrate d...
Gopal Kushawah, Victor Daniel Aldas Bulos, Danielson Baia Amaral et al.· bioRxiv· 1 citation
Maternal mRNA decay is essential for the Maternal-to-Zygotic Transition (MZT), yet its impact on spatial regulation has remained largely unexplored. We identify Cth1 as the first maternally encoded RNA-decay factor regulated in a spatiotemporal manner outside the germline in zebrafish, driven by conserved 3′UTR cis-ele...
Gopal Kushawah, Victor Daniel Aldas Bulos, Danielson Baia Amaral et al.· bioRxiv· 1 citation· ⚡1
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