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Open access Oct 2026

Microstructural heterogeneity of white-matter aging and its age-dependent coupling to cognition

Brain white matter (WM) microstructure undergoes extensive changes with age, yet the regional and cellular heterogeneity of age-related WM alterations and their impact on cognition remain unclear. Leveraging Neurite Orientation Dispersion and Density Imaging (NODDI), an advanced microstructural modelling to capture spe...

R. Chin, Xiao-Yang Hu, Jasmine Ranieri et al. · 0 citations
Open access Sep 2026

Tau‐PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head‐to‐head comparison of Flortaucipir and MK6240

Abstract INTRODUCTION We compared the association between mild behavioral impairment (MBI) and first‐ versus second‐generation tau‐positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD). METHODS We assessed 110 individuals with head‐to‐head [18F]MK6240 and [18F]Flortaucipir tau...

I. Bizzi, Arthur C. Macedo, Lydia Trudel et al. · 0 citations

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