Microfluidic channel engineering for mRNA-LNPs: a systematic review of mixing strategies, nanostructures, and biological performance.
mRNA-lipid nanoparticles (mRNA-LNPs) have revolutionized nucleic acid therapeutics, yet their clinical success relies heavily on precise manufacturing processes. This review comprehensively explores the critical intersection between microfluidic channel design, lipid self-assembly biophysics, and the subsequent biologi...