Author

Hyewon Park

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Open access Oct 2026

Contribution of Topoisomerase IIα chromatin-tether and C-terminal domain to mitotic chromosome association and structural organization.

Mitotic functions of Topoisomerase IIα (TopoIIα) are dictated by its C-terminal domain (CTD), which is distinct from TopoIIβ. The chromatin-tether domain (ChT) within the αCTD recognizes methylated chromatin, an ability lacking for TopoIIβ and loss of αChT leads to ultrafine DNA bridges (UFBs) and chromosome bridges in...

B. Lama, Sanjana Sundararajan, A. Saraf et al. · Journal of Cell Science · 0 citations

#machine learning Preprint Sep 2026

Discrete Score Matching Enables Causal Discovery from Count Data

Count data pose a challenge for score-matching-based causal discovery: derivatives are unavailable, and simply replacing them with finite differences does not generally suffice for causal discovery. We generalize SCORE's constant-curvature criterion (Rolland et al., 2022) by conditioning on the node's value, yielding t...

Euijong Song, Hyewon Park, Gunwoong Park · 0 citations