Ursolic acid attenuates LPS-induced cognitive dysfunction through the modulation of oxidative stress, neuroinflammation, and hippocampal synaptic plasticity.
BACKGROUND Neuroinflammation and oxidative stress play vital roles in the pathogenesis of neurodegenerative diseases characterized by cognitive decline. Ursolic acid (UA), a natural pentacyclic triterpenoid compound with reported anti-inflammatory and antioxidant properties, has been suggested as a potential neuroprote...