Functional and Mechanistic Characterization of SARS-CoV-2 NSP15 Reveals Metal-Dependent Regulation and Inhibition by Direct-Binding Small Molecules.
The SARS-CoV-2 non-structural protein 15 (NSP15) is a uridine-specific endoribonuclease involved in viral RNA processing and immune evasion, thereby contributing to viral pathogenesis. Although NSP15 has been structurally characterized by several studies, which report its endoribonuclease activity and regulatory featur...