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Author

I. Bello

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2 papers indexed here

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Open access Oct 2026

Structure-Based Design of HDAC6 Inhibitors Targeting the L2 Pocket: Modulating Autophagy and Liquid−Liquid Phase Separation in Lung Cancer

X-ray co-crystal structures of second-generation inhibitors 19b and 20b within zHDAC6 CD2 confirmed that these compounds behave as highly potent HDAC6 inhibitors with the ability to engage the S531 residue in the L2 loop HDAC6 catalytic domain.

Simona Barone, Abraham Eafa, I. Bello et al. · 0 citations
Open access Sep 2026

Molecular Hybrids of Deflazacort and H2S Donors: From Bench to Potential Treatment for Duchenne Muscular Dystrophy

Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disorder characterized by oxidative stress, chronic inflammation, and skeletal muscle degeneration. Although deflazacort is the standard treatment, its long-term use is associated with significant adverse effects. Since impaired hydrogen sulfide (H2S) sig...

V. Casale, Rosa Sparaco, Pierfrancesco Cinque et al. · 0 citations

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