Open access
Sep 2026
IL-21R blockade reduces inflammation and atherosclerosis in LDL receptor deficient mice.
BACKGROUND Interleukin-21 (IL-21) is a pro-inflammatory cytokine involved in the regulation of both innate and adaptive immune responses and has been associated with atherosclerotic cardiovascular disease (ASCVD). However, the exact role of IL-21/IL-21R signaling in atherosclerosis and the therapeutic potential of targ...
R. Snijckers, V. Smit, R. Postel et al.
· Atherosclerosis · 0 citations