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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

I. Budin

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Open access Aug 2026

Lipid-driven membrane remodeling engages a lysosome-dependent adaptive repair program during retinal aging

Age-associated remodeling of membrane lipid composition has been implicated in cellular dysfunction, yet the mechanisms linking lipid changes to membrane integrity and disease remain poorly defined. In the retinal pigment epithelium (RPE), lipid dysregulation is strongly associated with aging and age-related macular de...

Emily Tom, Fang-Yuan Gao, Carolina N. Franco et al. · 0 citations
Review Oct 2026

Lipid Chemistry beyond the Bilayer: Roles for Nonbilayer Lipids in Biology, Disease, and Delivery.

Cell membranes are composed of both bilayer and nonbilayer lipids, whose molecular shape and interactions support or oppose their packing into flat bilayer sheets. While the role of the former in maintaining membrane structural integrity is clear, a growing body of data highlights the importance of nonbilayer lipids in...

D. Milshteyn, I. Budin · 0 citations
Open access Aug 2026

Energetics of stalk intermediates elucidated from hydrostatic pressure effects on membrane fusion

Membrane fusion is an essential process in cells that requires a balance of lipid composition to establish biophysical properties conducive to topology changes. During fusion, lipids of opposing membranes must invert and overcome energy barriers associated with forming highly curved stalk and pore intermediates. While...

D. Milshteyn, J. Winnikoff, J. Morgan et al. · 0 citations

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