Open access
Jul 2026
ThermoFusion: A Multimodal Deep Learning Framework for Generalizable Prediction of Enzyme Thermostability
ThermoFusion, a hybrid deep learning framework that integrates 3D protein structure embeddings from ThermoMPNN with sequence-based embeddings from the pretrained protein language model ESM2 to predict the effects of single-point mutations on protein stability is presented.
Yao Wei, I. Eberini, Fabian Meyer
· bioRxiv · 0 citations