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I. Faggiani

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Review Open access Aug 2026

Inflammatory and Immune Pathways Driving Tumor Necrosis Factor Inhibitor Resistance in Ulcerative Colitis

Abstract Ulcerative colitis (UC) is a chronic immune-mediated inflammatory disease characterized by dysregulated mucosal immunity in genetically susceptible individuals exposed to environmental and microbial triggers. Tumor necrosis factor-alpha (TNF-α) antagonists have transformed the management of moderately-to-sever...

Morgan Fairweather, I. Faggiani, Christopher Ma · 0 citations

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