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I. Finkelberg

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Open access Aug 2026

Melanocortin-4 Receptor Regulation of Endocrine Axes and Clinical Effects of Setmelanotide.

Setmelanotide exerts pleiotropic effects beyond weight reduction, modulating multiple endocrine axes in BBS, and the observed changes highlight MC4R signaling pathway as a key integrator of metabolic and endocrine function and suggest partially weight-independent therapeutic effects.

T. Hühne, E. Steidel, J. Holland et al. · 0 citations