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Author

I. Forné

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Open access Sep 2026

Multi-omic dissection of reversible and persistent molecular alterations in diet-induced obesity

Diet-induced obesity drives broad molecular remodeling across host and microbial systems, but why lifestyle intervention reverses some of these alterations while others persist remains unclear. To address this, we performed a multi-omic characterization of diet-induced obese mice after a combined nutritional and exerci...

Jordi Rofes, Joan Miro-Blanch, Pau Gama-Pérez et al. · 0 citations
Open access Aug 2026

RNA-dependent association of the pyruvate dehydrogenase complex with mtDNA-containing assemblies supports mitochondrial translation

It is shown that the pyruvate dehydrogenase complex (PDHc), which supplies acetyl-CoA to the tricarboxylic acid cycle, is a component of this machinery in Saccharomyces cerevisiae and acts as a non-catalytic component of the RNA-dependent architecture that supports mitochondrial gene expression.

Johannes Hagen, Nupur Sharma, Felix Thoma et al. · 0 citations
Open access Jul 2026

Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing

A high-throughput clustered regularly interspaced short palindromic repeats (CRISPR) prime editing platform enabling precise, reversible and combinatorial mutagenesis of canonical and noncanonical histone H3 genes within their native genomic context is developed.

Daniel Price, Grigory Zemlyanskiy, Watanya Trakarnphornsombat et al. · 2 citations

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