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I. Kostakis

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Open access Aug 2026

Chemoproteomics identifies a pyrimido[4,5-d]pyrimidine analogue as a tubulin-tyrosine ligase binder

This work serendipitously identified CEM198 as the first high-affinity ligand of tubulin-tyrosine ligase (TTL), introducing CEM198 as a chemical probe for investigating the tubulin tyrosination–detyrosination and demonstrating the potential of chemoproteomics to uncover novel modulators of microtubule dynamics.

Rubaba R. Abanti, Eleftheria A. Georgiou, D. Makarov et al. · 0 citations

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