Open access
Sep 2026
TDP-43 dysfunction induces cryptic circular RNAs in ALS/FTD
Nuclear depletion of TDP-43 is a defining pathological feature of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), leading to widespread RNA misprocessing, including the formation of cryptic exons. Here, we identified TDP-43 as a regulator of circular RNA (circRNA) biogenesis in multiple human neu...
Dario Dattilo, F. Pellegrini, Simone Barattucci et al.
· bioRxiv · 0 citations