Author

I. Liu

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Open access Sep 2026

A massively parallel synthetic gene atlas for learning compact cis-regulatory grammar across cellular contexts

Virtual-cell models increasingly learn from large perturbation atlases, but their view of cis regulation remains limited to endogenous genes embedded in broad native regulatory contexts. Here we introduce Therna Biosciences’ Chronos platform and its first public dataset release, comprising two complementary modules of...

Timo Hagen, I. Liu, Ariana Nagainis et al. · bioRxiv · 0 citations

Open access Aug 2026

Cortical organoids reveal human-specific role of METTL5 in neurodevelopment via regulation of CHCHD2

Overexpression of CHCHD2 in METTL5-KO NPCs rescued proliferation and partially rescued oxidative metabolism in NPCs and ventricle formation in organoids, highlighting a previously uncharacterized connection between CHCHD2, oxidative metabolism, and METTL5-mediated regulation of human neurogenesis.

Elena M. Turkalj, Gugene Kang, I. Liu et al. · Stem Cell Reports · 0 citations