Author

I. Maze

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Open access Sep 2026

KMT2E recruitment by H3 serotonylation regulates neurodevelopmental chromatin dynamics

Histone H3 Gln 5 serotonylation (H3Q5ser) is a recently identified epigenetic modification in brain that modulates reader interactions with adjacent H3 Lys 4 trimethylation (H3K4me3) to promote transcriptional permissiveness1,2. However, whether H3K4me3Q5ser and its associated binding proteins regulate neurodevelopment...

Jennifer C. O'Chan, Benjamin H. Weekley, Ce-Li Yang et al. · bioRxiv · 0 citations

Open access Sep 2026

Drosophila and human transglutaminases are partially interchangeable, revealing evolutionary conserved roles in brain development

Transglutaminases (TGs) are a family of enzymes characterized by their calcium-dependent transamidation activity. In higher mammals, TG2 is the family member with the highest expression in the brain. Intriguingly, TG2 KO mice show no major neurodevelopmental abnormalities, which might be explained by compensation f...

Isidora Almonacid-Torres, Joaquín Almonacid-Torres, Paulina Gómez-Fett et al. · Cellular and Molecular Life... · 0 citations

Review Aug 2026

Early life experiences, the neural epigenome and affective disorder risk

Recent advances in cell-type-specific epigenetic and transcriptional mechanisms underlying long-term stress susceptibility are discussed, which suggest peripheral epigenetic signatures associated with early life stress may provide accessible biomarkers of exposure and disease risk.

Ashley M. Cunningham, I. Maze · Nature Reviews Neuroscience · 1 citation