I. Mir-Sanchis

Structural basis of self-loading by replicative helicases

DNA replication is conserved in all forms of life on earth, from subcellular structures such as viruses to human cells. Here we study a group of virus parasites whose replication is initiated by helicases like those found in simian viruses and eukaryotic cells. The process by which these viral helicases initiate the re...